| Insert |
DNA: genomic Insert lengths(kb): 1.600000023841858 Tissue: HOS cell line DNA transferred into NIH 3T3 cells Gene product: met proto-oncogene(hepatocyte growth factor receptor) [MET] Alleles: D1, D2, D1, D2, A2, B2, A2, B1, B2, A1, A1, A2, A2, B1, C1, C2, A1, A1, A1, A2, A2, C1, C2, A1 |
| Comments |
Restriction digests of the clone give the following sizes (kb): SalI/EcoRI--4.2, 1.25; SalI--5.5; EcoRI--5.5. NIH 3T3 cells were transformed with DNA from the osteosarcoma HOS cell line which had been treated with N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). DNA from secondary transfectants was used to isolate the clone. |
| References |
Park M, et al. Sequence of MET protooncogene cDNA has features characteristic of the tyrosine kinase family of growth factor receptors. Proc. Natl. Acad. Sci. USA 84: 6379-6383, 1987. PubMed: 2819873
Jacobsen SJ, et al. A clinically homogeneous group of families with facioscapulohumeral (Landouzy-Dejerine) muscular dystrophy: linkage analysis of six autosomes. Am. J. Hum. Genet. 47: 376-388, 1990. PubMed: 1975474
White R, et al. A closely linked genetic marker for cystic fibrosis. Nature 318: 382-384, 1985. PubMed: 3906407
Cooper CS, et al. Molecular cloning of a new transforming gene from a chemically transformed human cell line. Nature 311: 29-33, 1984. PubMed: 6590967
Dean M, et al. The human met oncogene is related to the tyrosine kinase oncogenes. Nature 318: 385-388, 1985. PubMed: 4069211
Lathrop GM, et al. Refined linkage map of chromosome 7 in the region of the cystic fibrosis gene. Am. J. Hum. Genet. 42: 38-44, 1988. PubMed: 2892400
Julier C, White R. Detection of a NotI polymorphism with the pmetH probe by pulsed-field gel electrophoresis. Am. J. Hum. Genet. 42: 45-48, 1988. PubMed: 2892401
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