This validated panel is composed of 9 select human tumor cell lines carrying c-myc mutations or various degrees of c-myc gene copy number changes, and is useful for MYC pathway research and for anti-cancer drug discovery.
Biosafety Level
2 [Cells contain Herpesvirus (EBV)]
Biosafety classification is based on U.S. Public Health Service Guidelines, it is the responsibility of the customer to ensure that their facilities comply with biosafety regulations for their own country.
Comments
MYC is an oncogenic transcription factor which is encoded by the c-myc proto-oncogene. By regulating target gene expressions, MYC has diverse roles involved in cell growth, proliferation, biogenesis, cellular metabolism and apoptosis. Mutations or overexpression of c-myc gene has been detected in a wide range of human cancers, especially in lymphomas.
The MYC genetic alteration cell panel (ATCC TCP-1035) is composed of nine selected human tumor cells that carry c-myc mutations or various degrees of c-myc gene copy number changes. The MYC status of each cell line has been sequenced and validated by ATCC. This panel is useful for studying MYC and its cellular effects on subsequent target genes and pathways in providing a platform for basic research and anti-cancer drug discovery.
Product Format
frozen 9 cryopreserved cell lines
Storage Conditions
liquid nitrogen vapor phase (less than -130°C) only
